The term "most well-disposed" refers to individuals who are friendly, agreeable, and favourable towards others. Antonyms for this phrase would be adversarial, hostile, and unfriendly. People who are adversarial tend to be contentious, confrontational, and combative towards others. Hostile individuals are unfriendly, aggressive, and often display negativity towards others. Lastly, unfriendly individuals are indifferent, aloof, and stand-offish. These individuals are not forthcoming with their emotions or willing to engage in social interactions. In contrast, the antonyms for "most well-disposed" imply that individuals are more likely to act out of malice than with goodwill towards others.