The phrase "most wide-eyed" typically refers to someone who is extremely innocent and naive. Antonyms for this phrase would include words such as worldly, sophisticated, experienced, jaded, and cynical. These words suggest a person who has seen and experienced a lot in the world, and has become more realistic and less trusting as a result. Instead of being easily impressed and eager to believe anything, someone who is the opposite of "most wide-eyed" would be more skeptical and discerning, with a more nuanced understanding of human nature and the world around them.