Antonyms for the word "most wound-up" include relaxed, calm, composed, unworried, and serene. These words describe a state of tranquility, where the individual is not overwhelmed with stress, anxiety or tension. Relaxed refers to a sense of ease or comfort, while calm describes a state of serenity and peacefulness. Composed means to be in control of one's emotions, and unworried suggests a lack of concern or anxiety. Serene is a term that conveys a state of inner calm and tranquility. So, instead of feeling most wound-up, one can strive to be relaxed, calm, composed, unworried, or serene to achieve a state of balance and inner harmony.