Multidimensional chromatography refers to the separation and analysis of complex mixtures using several separation techniques. There are several synonyms for multidimensional chromatography that scientists use depending on the specific separation techniques used. Some of these synonyms include comprehensive two-dimensional gas chromatography (GCxGC), two-dimensional liquid chromatography (LCxLC), hyphenated techniques, and multi-dimensional liquid chromatography (MDLC). Scientists use these techniques to separate analytes that are present in extremely low concentrations, as well as to separate compounds that have similar or identical chemical structures. Multidimensional chromatography plays a vital role in various fields, such as pharmaceuticals, environmental testing, and food analysis, helping scientists achieve accurate and reliable results.