Murphys buttons sign, also known as inspiratory arrest or the "Catch-22" sign, refers to the characteristic medical finding observed in patients with acute cholecystitis. This condition occurs when there is inflammation in the gallbladder, leading to pain and tenderness in the right upper abdomen. The term "Murphys buttons sign" is derived from a clinical test performed by pressing on the area over the gallbladder and asking the patient to take a deep breath. If there is a halt in inspiration due to pain, it indicates a positive sign. Synonyms for this medical sign include inspiratory arrest sign, gallbladder catching sign, and acute cholecystitis indicator.