Neddylation is a process that involves the covalent attachment of the protein Nedd8 to a target protein. This process is important for the stability and function of many proteins, and dysregulation of neddylation has been implicated in various diseases. Synonyms for neddylation include Nedd8 conjugation, Nedd8 modification, and Nedd8ylation. Other related terms include ubiquitination, sumoylation, and acetylation, which similarly involve the addition or removal of small protein moieties to modify the function of proteins. Understanding the mechanisms and regulation of neddylation and related processes is essential for developing targeted therapies for diseases linked to protein dysregulation.