Neurofibrillary tangle, a pathological hallmark of neurodegenerative diseases like Alzheimer's, can be understood through its synonyms. Firstly, it is commonly referred to as NFT, which stands for neurofibrillary tangle. Another equivalent term is "tau tangles", as these abnormally twisted protein filaments primarily consist of tau protein. Additionally, it can be called "neurofibrillary degeneration", as this condition leads to the breakdown of vital brain cells. Moreover, it may be mentioned as "paired helical filaments" due to their helical structure under a microscope. By exploring these synonyms, one can gain a better comprehension of the characteristics and impact of the neurofibrillary tangle within the context of neurodegenerative diseases.