"Nopers" is a colloquial slang term often used as a playful way to express the negative response of "no" or "not at all". While "nopers" may not have many literal synonyms, there are various alternative expressions that carry a similar meaning. Common synonyms include "nope", "nah", "negative", "not a chance", "not happening", "not on your life", "uh-uh" or "no way". These synonyms can be used interchangeably with "nopers" to convey a clear disapproval or denial. Each variation brings its own unique tone or level of informality, allowing individuals to choose the expression that best suits their communication style and context.