The opposite of "kindred" has various interpretations depending on the context. In situations where it refers to family or relatives, the antonyms could be strangers, non-relatives, or unrelated. In the case where "kindred" implies a common origin, descent, or affinity, the antonyms may include dissimilar, divergent, or unalike. Whereas, if it refers to a shared culture, nationality, or ethnicity, then the antonyms would be different, foreign, or unconnected. In general, "not kindred" can be interpreted as anything that does not share a connection or similarity, including opposing, conflicting, opposing, or unrelated.