When it comes to describing someone or something as a clear favorite, there are numerous alternatives to the phrase "odds-on-favorite." For instance, you could use the term "front-runner" to describe a person or team with a significant advantage over its competitors, while someone with an almost certain chance of winning could be referred to as a "shoo-in." Another popular synonym for "odds-on-favorite" is "sure thing," which conveys a high degree of confidence that something will happen or someone will win. Other common expressions to convey similar meaning include "slam dunk," "solid bet," and "top contender," among others.