Antonyms for the phrase "one best guess" would include terms such as uncertain, unsure, doubtful, indecisive, and speculative. Antonyms for "best" may include mediocre, poor, substandard, or lackluster. Similarly, antonyms for "guess" may include certitude, assurance, knowledge, certainty, or conviction. Using these antonyms together, one could describe a situation where someone has multiple poor or lackluster guesses, leaving them unsure, doubtful, and indecisive about the correct answer. Conversely, they may have a high level of certitude and assurance about the right answer due to their knowledge or certainty on the subject matter.