There are many synonyms for the phrase "one in disgrace." Some common terms include "shamed," "humiliated," "dishonored," "discredited," and "disgraced." Other related words might include "ostracized," "rebuked," "condemned," "scorned," and "reproached." Depending on the context, different words may be more appropriate than others. For example, someone might be "shamed" after being caught in a lie, while another person might be "discredited" after a scandal involving fraud. Regardless of the specific term used, being "in disgrace" implies a loss of honor or reputation that can be difficult to recover from.