One's damndest is an expression used to describe an individual's effort to do something to the best of their ability. synonyms for this phrase include doing one's best, giving it one's all, exerting oneself to the utmost, going all out, leaving no stone unturned, and putting in one's maximum effort. These expressions convey the same intensity and dedication as one's damndest. People use these synonyms to emphasize the importance of putting in the necessary effort and hard work to achieve their goals. No matter the phrase used, the message is clear - put in the work and strive for excellence.