Out-growth, as a noun, refers to something that has grown out of or been produced by a larger thing, such as a branch on a tree or a project that stemmed from a company's initial idea. The opposite of an out-growth would be an in-growth, meaning something that has grown inward, such as a hair follicle or a tumor. Another antonym could be a regression, which refers to a return to a previous state or a decline in progress. A third option could be a reduction or decrease, which would be the opposite of growth altogether. Ultimately, the antonym for out-growth would depend on the context and definition being used.