"Patsiest" is a slang term used to describe something that is excessively easy or simple to do. Its antonyms would, therefore, be words that describe something difficult or challenging. Some possible antonyms for "patsiest" include words like challenging, demanding, intricate, complex, difficult, and hard. These words indicate that a task or situation requires a high level of skill, knowledge, or effort to accomplish successfully. If something is described as the opposite of "patsiest," it suggests that you will need to put in a lot of effort and hard work to achieve your goals.