PEDF, also known as pigment epithelium-derived factor, is a protein that has anti-angiogenic and neurotrophic properties. It is a widely researched molecule with various synonyms, such as SERPINF1, EPC-1, and PICEF. SERPINF1 is the official gene symbol for PEDF, which stands for Serpin Family F Member 1. EPC-1 represents Endothelial cell protein C/activated protein C receptor 1, which is a receptor for PEDF. PICEF stands for Proliferation and differentiation-inducing activity associated with the protease inhibitor EPPIN. Other synonyms include 34-kDaPEDF, GDNF-inducible factor, and SDPN. The significance of these synonyms is that they help researchers access different databases and literature related to PEDF.