PEGylation is a process that has proved to be critical in the biomedical field. PEGylate refers to the addition of polyethylene glycol (PEG) molecules to drugs, proteins, or surfaces to increase their solubility, biological half-life, and stability. However, there are several other terms that have the same meaning as PEGylation, including PEG conjugation, PEG modification, PEG functionalization, and PEG attachment. These synonyms help to explain the process of PEGylating different substances, but they all correspond to the same method of improving the performance of drugs and other compounds. Thus, PEGylation is an essential technique that continues to play a vital role in drug delivery and other related fields.