Pericardial space is a medical term that refers to the sac filled with fluid that surrounds the heart. This space has several synonyms that can be used interchangeably in medical literature. Some of the other terms that can be used as synonyms for pericardial space include pericardium, pericardial sac, pericardial cavity, epicardial space, and cardiac envelope. Moreover, there are some additional synonyms such as pericardial effusion which refers to an accumulation of excess fluid in the pericardial space and pericardiocentesis which is a procedure of draining the excess fluid out of the pericardial sac. Awareness of these synonyms can help healthcare professionals to enhance their knowledge and provide better healthcare to the patients.