Polyomaviruses Large T Proteins are a group of proteins with vital roles in the polyomavirus family. These proteins play significant functions in viral replication, transcriptional regulation, and cell cycle control. Synonymous terms for Polyomaviruses Large T Proteins include Large Tumor proteins due to their association with tumor formation and oncogenesis. Additionally, they are known as Viral T antigens, highlighting their viral origin and contribution to infection. These synonymous names emphasize the critical role these proteins play in viral pathogenesis and their potential as targets for therapeutic interventions to combat diseases caused by polyomaviruses.