Prenanthes purpurea, commonly known as the purple lettuce, is a flowering plant native to North America. This herbaceous perennial belongs to the Asteraceae family and is known for its medicinal properties. Purple lettuce is rich in compounds such as sesquiterpene lactones, phenolics, flavonoids, and coumarins, making it a valuable plant in traditional medicine. When it comes to synonyms for Prenanthes purpurea, common names include purple rattlesnake root, lion's foot, bitter lettuce, and gall-of-the-earth. These names reflect the plant's traditional uses in treating ailments such as rheumatism, digestive disorders, and snake bites. Regardless of the name used, Prenanthes purpurea remains a treasured and significant plant in traditional medicine.