To prevail against means to triumph over a challenge, difficulty, or opposition. Some synonyms for prevail against are to overcome, conquer, defeat, vanquish, overpower, subdue, crush, master, and win. Overcoming difficulties requires determination, perseverance, and strength. To conquer means to gain control or victory over someone or something. To defeat means to win a battle or overcome an enemy. Vanquish means to defeat an opponent thoroughly. To overpower means to overcome someone with superior strength or force. Subdue means to bring someone or something under control by force or persuasion. Crushing means to defeat someone or something completely. Master means to become proficient in a particular skill or subject. Winning means achieving victory over someone or something.