There are several synonyms for the phrase "prey to malaise," which refers to being overcome by a general feeling of unease or discomfort. Some alternative phrases that convey a similar meaning include "plagued by lethargy," "afflicted with ennui," and "suffering from listlessness." Other words that can be used to describe this condition include "depressed," "weary," "fatigued," and "apathetic." While the underlying causes of malaise can vary, it is often associated with a lack of purpose or meaning in one's life, as well as physical or mental exhaustion. To combat malaise, it may be helpful to seek out new experiences, engage in self-care, or connect with others who share your interests or values.