Proenkephalin is a substance found in the human brain that is responsible for producing natural painkillers known as enkephalins. Synonyms for the term proenkephalin include preproenkephalin, PENK, and enkephalin precursor. These terms are often used interchangeably in scientific literature to refer to the same substance. Proenkephalin is an important component of the body's pain management system and is involved in the regulation of mood, learning, and memory. It is also believed to be involved in the development of addiction and tolerance to opioid drugs. Research on proenkephalin and its role in the body continues to advance our understanding of pain management and addiction treatment.