Proopiomelanocortin (POMC) is a polypeptide hormone that is mainly associated with regulating appetite and metabolism. However, there are several synonyms that are commonly used in the scientific community. These include proadrenocorticotropin, corticotropin precursor, melanotropin-lipotropin, and beta-lipotropin. Each of these terms refers to the same precursor molecule that is eventually processed into several biologically active peptides. POMC is primarily produced in the pituitary gland and hypothalamus of the brain, and its functions are numerous and complex. Identifying and understanding the various synonyms for POMC can be helpful in clarifying scientific research and communication about this important hormone.