Protein structure is one of the most important components when it comes to understanding the behavior and function of proteins. There are various terms used as synonyms for protein structure such as protein conformation, protein folding, protein shape, and protein architecture. Protein conformation refers to the three-dimensional arrangement of atoms in a protein molecule, whereas protein folding is the process by which a protein acquires its conformation. Protein shape refers to the spatial arrangement of several aspects of protein structure, such as the secondary and tertiary structures. Protein architecture refers to the overall organization of a protein and includes its sequence and topology. All these terms describe the various aspects of protein structure and are essential for understanding the complex roles played by proteins in biological systems.