Proteopathy is a term used to describe a group of diseases that are characterized by the abnormal accumulation of proteins in organs, tissues or cells. There are several synonyms that are used to describe proteopathy such as proteinopathy, amyloidosis, and protein misfolding disorders (PMDs). Another commonly used term is conformational disease which describes diseases caused by abnormal folding of proteins. Other terms that may be used to refer to proteopathy include protein aggregation disease, protein deposition disease, and protein sanctuary disease. While these terms have slight variations, they all describe the same group of diseases. Understanding the different terms used to describe proteopathy can help with the diagnosis and treatment of these conditions.