Protopine is a natural alkaloid that can be found in certain plants like Corydalis and Papaver. Apart from its medicinal properties, several synonyms are associated with protopine due to its chemical nature and usage in various compounds. Clematidine, atherospermidine, β-N-methylprotoberberine, cryptopine, and protopinol are among the common synonyms for protopine. These synonyms reflect the different aspects and functions of protopine in chemical and therapeutic fields. For instance, β-N-methylprotoberberine is an intermediate in the synthesis of berberine, which has potent antimicrobial properties. cryptopine, on the other hand, is a precursor to several opium alkaloids synthesized from protopine. Overall, these synonyms demonstrate the versatility and significance of protopine in different applications.