The word "puzzlehead" is quite a unique term and cannot be easily replaced by any other word. However, there are several synonyms that can be used to describe someone who is confused, perplexed or bewildered. Some of these synonyms include "bewildered," "confused," "discombobulated," "perplexed," "flustered," "mystified," and "baffled." These synonyms could be used to describe a person who is struggling with a problem or situation that is difficult to understand. While "puzzlehead" may have a lighthearted tone to it, these other synonyms may carry a more serious connotation. Regardless of the synonym used, it is clear that the person in question is facing a challenging situation and may require extra help or support to overcome it.