Quick-wittedly is a term that is used to describe someone who is sharp, clever, and able to think on their feet. There are a number of synonyms that can be used to describe this quality, including astutely, sharply, shrewdly, cleverly, intelligently, sagaciously, and keenly. These words all convey the idea of someone who is able to quickly and accurately assess a situation and come up with a smart response. Whether you are describing a person's wit, intelligence, or overall mental acuity, you can choose from a wide range of synonyms to find the perfect word to capture their quick-wittedness.