The phrase "resign to" usually means to surrender or accept a situation, often with reluctance or disappointment. Antonyms for this phrase would include "fight against," "resist," "refuse," "disapprove," or "reject." These words denote a sense of rebellion or opposition, suggesting a determination to change or challenge what is currently happening. "Embrace," "welcome," or "embrace" could also be considered antonyms, as they convey a sense of acceptance or enthusiasm for a situation. Ultimately, the opposite of "resign to" would depend on the context or circumstances of the situation in question, but antonyms like these suggest a desire for change or a refusal to simply accept things as they are.