Rett disorder, also known as Rett syndrome, is a rare genetic neurological disorder primarily affecting girls. This debilitating condition leads to severe cognitive and physical impairments. Synonyms for Rett disorder include Rett syndrome, Rett's syndrome, cerebroatrophic hyperammonemia, Rett's disorder, and autism disorder. Individuals with Rett disorder often experience developmental regression, loss of purposeful hand skills, breathing problems, seizures, and intellectual disabilities. Although there is currently no cure for Rett disorder, various therapies and interventions can help manage symptoms and improve quality of life for those affected. It is crucial to raise awareness and provide support for individuals living with this complex disorder and their families.