The phrase "run a game on" means to deceive or play a trick on someone. Antonyms for this phrase might include being honest or straightforward with someone, telling the truth, or playing fair. Other antonyms might include treating others with respect, having integrity, or avoiding manipulation. When we choose to be truthful and avoid deceiving others, we build trust and respect in our relationships. So, instead of running a game on someone, we can opt to communicate clearly and without deceit, allowing us to establish stronger and more authentic connections with those around us.