S Damnosum, also known as "river blindness", is a parasitic infection caused by the worm Onchocerca volvulus. This debilitating disease affects millions of people in Africa, particularly those living near rivers. Synonyms for S Damnosum include fluvial Onchocerca volvulus, river worm, and black fly. The black fly is a vital component in the transmission of these worms as it acts as an intermediate host. S Damnosum can cause severe itching, skin lesions, and even blindness. Efforts to control and eliminate S Damnosum involve vector control, such as insecticide-treated bed nets and larvicides, as well as the distribution of medication called ivermectin. It is crucial to raise awareness about this disease to improve affected communities' quality of life and accelerate progress towards its eradication.