"Set little by" is an idiomatic expression which means to attach little value or importance to something. There are several synonyms for this phrase such as "neglect", "disregard", "ignore", "underestimate", "devalue", and "undervalue". Neglect is the failure to pay attention to something that deserves consideration, while disregard means to show no interest or concern. Ignoring something means not acknowledging its importance or existence, whereas underestimating or undervaluing something means not appreciating its worth. All of these synonyms can be used interchangeably with "set little by" to indicate that something is not highly valued or considered unimportant or insignificant.