"Set on edge" is a common expression that refers to a state of being uneasy, irritated, or agitated. Synonyms for this phrase include phrases like "put on edge," "make uneasy," "unsettle," and "discomfit." Another synonym for this phrase is "nervous wreck." It's a state of being that is uncomfortable and can be caused by a variety of things, including stress, anxiety, and fear. When one is "set on edge," it is important to address the underlying cause so that they can return to a state of calm and peace. Trying to remain calm, going for a walk or speaking with a trusted friend can help alleviate the feeling.