"Setting on edge" is an idiom used to describe a feeling of unease or discomfort. Some synonyms for this term include "making uneasy," "unsettling," and "nerving." Other synonyms that convey a sense of tension or anxiety include "uncomfortable," "anxious," "edgy," "nervous," and "apprehensive." Additionally, words like "irritating," "irksome," and "grating" can also be used to describe situations or people that cause a sense of unease. Overall, there are many words in the English language that can be used to convey the feeling of being on edge, reflecting the complex nature of human emotions and experiences.