Single Peroxisomal Dysfunction refers to a rare genetic disorder that affects the peroxisomes, small cell organelles responsible for various metabolic processes in the body. This condition is characterized by a dysfunction or abnormalities in a single peroxisome, leading to impaired functioning. Though it has no specific synonyms, it shares similarities with other peroxisomal disorders like Zellweger syndrome, rhizomelic chondrodysplasia punctata, or X-linked adrenoleukodystrophy, as they all involve the malfunctioning of peroxisomes. Individuals with Single Peroxisomal Dysfunction may exhibit symptoms such as developmental delays, seizures, vision and hearing problems, and liver abnormalities. Early diagnosis and intervention play a crucial role in managing the condition and improving the quality of life for patients.