The term "Sixth Disease" refers to a childhood illness known as Roseola. This common viral infection predominantly affects infants and young children, causing a distinct rash and high fever. Although it is colloquially referred to as the "Sixth Disease", there are a few other synonymous names used to describe this condition. Some of the alternative terms for Roseola include Exanthem Subitum, Three-Day Fever, and Roseola Infantum. These names refer to the sudden appearance of a rash following a bout of high fever lasting around three days. Understanding the numerous synonyms for the "Sixth Disease" aids in effective communication and identification of this relatively benign childhood ailment.