Antonyms for the term small difficulties are vast and varied. The most common antonyms include large hurdles, significant obstacles, major problems, and immense challenges. These are the kind of difficulties that require a greater level of attention, resources, and time to overcome. They can range from financial struggles to chronic health conditions or natural disasters. Other antonyms may include substantial impediments, formidable barriers, and serious setbacks. Regardless of the antonym, it is clear that small difficulties pale in comparison to the larger, more complex issues that people face. Overcoming these larger obstacles requires grit, determination, and sometimes a little bit of luck.