The smooth endoplasmic reticulum (SER) is a structure within a cell that is involved in various processes, such as lipid metabolism and drug detoxification. There are several synonyms that are used to refer to the smooth endoplasmic reticulum, including agranular endoplasmic reticulum (AER), sarcoplasmic reticulum (SR), and tubular endoplasmic reticulum (TER). The term AER is often used to denote the lack of ribosomes on the smooth endoplasmic reticulum compared to the rough endoplasmic reticulum. The term SR is commonly used in muscle cells, where it plays a vital role in calcium ion storage, release, and uptake. Lastly, the term TER emphasizes the tubular shape of the SER.