Solution-phase synthesis refers to a type of chemical synthesis that takes place in a liquid or solution medium. Alternative synonyms for this term may include liquid-phase synthesis, homogenous-phase synthesis, and solution-based synthesis. Additionally, the term may be used in conjunction with other descriptors, such as microwave-assisted solution-phase synthesis or solid-supported solution-phase synthesis, to indicate specific variations of the technique. Solution-phase synthesis methods are widely utilized in a variety of fields, including pharmaceuticals and materials science, due to their versatility and efficiency in producing compounds of interest. Understanding the different terms associated with solution-phase synthesis can aid researchers in selecting the appropriate method and expanding their synthetic toolbox.