Sphacele is a medical term which refers to the death of a tissue in the body, resulting from a lack of blood supply or severe injury. This condition is also commonly known as necrosis. There are several synonyms for sphacele, including gangrene, necrotic tissue, mortification, and tissue death. Gangrene typically refers to the death of tissue due to bacterial infection, whereas necrotic tissue refers to tissue that has died as a result of injury or disease. Mortification is another synonym for sphacele, and typically refers to the death of tissue or organ in the advanced stages of disease or injury. Regardless of the term used, sphacele often signifies a serious medical condition and should be evaluated immediately by a healthcare professional.