There are many synonyms for the phrase "stand in the way of," each with its own nuance. Some examples include obstruct, impede, thwart, hinder, block, disrupt, hamper, stymie, curb, and derail. When someone or something is standing in the way of something else, it is preventing it from progressing or being achieved. Each of these synonyms emphasizes a different aspect of this obstruction, such as the intentional interference suggested by thwart or the unexpected difficulties implied by derail. Ultimately, the choice of synonym will depend on the context and the precise meaning intended.