Structural variation refers to genetic differences that involve large segments of DNA, including insertions, deletions, and rearrangements. There are many synonyms for the term structural variation, including genomic rearrangement, copy number variation, large-scale genomic variation, chromosomal aberration, and genome rearrangement. These terms all describe different ways in which genetic material can vary between individuals, and they are important for understanding how genetic diversity arises and how it affects disease risk and other traits. By studying structural variation, researchers can gain insights into the mechanisms of genetic inheritance, and they can develop new strategies for diagnosing and treating genetic diseases.