Surefires are things that are certain or guaranteed. Antonyms for surefires would be words that represent uncertainty, doubt or unpredictability. Some antonyms for surefires are words like unsure, uncertain, unsureness, doubtfulness, unclear, hazy, dubious, and risky. These words represent situations where there is little or no certainty, where there is doubt or where things are not guaranteed. Surefires represent things that can be relied upon, while the antonyms for surefires represent the opposite, where there is no guarantee and it is not clear what will happen. Using these antonyms can help add depth and complexity to your writing and communication.