A systematic review is a type of research methodology that involves an exhaustive search for relevant literature and the critical appraisal of identified studies to answer a specific research question. The process of systematic review is guided by a pre-defined protocol that outlines the methods and procedures for the search, study selection, data extraction, and synthesis of results. Synonyms for systematic review may include meta-analysis, evidence synthesis, systematic literature review, comprehensive review, or robust review. These terms describe a process that follows a systematic and rigorous approach to identify and evaluate the quality of evidence, which can inform decision-making and policy development.