"Take in hand" is a phrase that denotes taking control or responsibility for a specific task or situation. There are multiple synonyms that can be used to convey the same meaning, such as "tackle," "address," "manage," "undertake," "shoulder," "assume," "grasp," "deal with," "get a grip on," "attend to," "handle," "seize," and "lead." Each of these synonyms signifies taking charge of a particular situation by adopting different approaches. Whether it is delegating tasks or lending a guiding hand, the synonyms provide various ways to express the notion of taking up a challenge or responsibility and dealing with it effectively.