Antonyms for the phrase "takes a chance" include terms such as "plays it safe," "avoids risks," "shies away from uncertainty," and "acts cautiously." Someone who takes a chance is often seen as daring, adventurous, or optimistic, while those who avoid risks are perceived as practical, reserved, or risk-averse. Different contexts may require different approaches, and sometimes taking a chance may lead to great rewards, while other times it can result in negative consequences. Ultimately, the decision to take a chance or play it safe depends on individual preferences, circumstances, and calculated risks.