The phrase "takes issue" essentially means to disagree or challenge a particular viewpoint. Therefore, some possible antonyms for this phrase could include "agree," "concur," "accept," "endorse," "support," "approve," "concede," or "acquiesce." Alternatively, one could also use phrases like "lets it pass," "ignores," or "avoids confrontation" to signify the opposite meaning of "takes issue." Depending on the specific context, there may be other words or phrases that could indicate opposing sentiments, but these are some general options that could be used.