Taking no chances means being very careful and taking every precaution possible. Synonyms for this phrase include being cautious, prudent, wary, vigilant, guarded, attentive, watchful, or safe. When we take no chances, we tend to be very sensible and mindful of potential threats or risks involved. It's important to use these synonyms in situations where it's imperative to be careful and not take any risks, especially when it comes to safety or security. Being cautious and vigilant are traits that are often considered to be positive and necessary for avoiding potential danger or harm.